Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals through the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have determined recurrent mutations in genes regulating tumor cell-microenvironment interac... https://creightonx009mbs7.oneworldwiki.com/user